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The Belgrade childhood diabetes study – comparison of children with Type 1 diabetes with their siblings
Author(s) -
Vlajinac Hristina,
Šipetić Sandra,
Marinković Jelena,
Bjekić Milan,
Kocev Nikola,
Sajić Silvija
Publication year - 2006
Publication title -
paediatric and perinatal epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.667
H-Index - 88
eISSN - 1365-3016
pISSN - 0269-5022
DOI - 10.1111/j.1365-3016.2006.00713.x
Subject(s) - medicine , diabetes mellitus , logistic regression , type 1 diabetes , disease , type 2 diabetes , demography , pediatrics , risk factor , punishment (psychology) , developmental psychology , endocrinology , psychology , sociology
Summary A case–control study was conducted in Belgrade (about 320 000 inhabitants 0–16 years old) during the period 1994–97, comprising 68 diabetic children (cases) and 68 controls chosen from the siblings of the cases. Analysis using multivariable logistic regression analysis indicated the following independent risk factors for Type 1 diabetes: higher birth order, infections during the 6 months preceding the onset of the disease and stressful events. Out of individual stressful and psychological factors, ‘other’ stressful events (severe accident or hospitalisation or death of a close friend, conflict with a teacher, death of a pet, failure in competition, quarrel between parents, punishment, physical attack, war in republics of former Yugoslavia and near drowning in the pool) and learning problems were independent risk factor for Type 1 diabetes. The results obtained in this study of siblings supports the hypothesis that environmental factors play a role in the development of Type 1 diabetes.