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The distribution of amyloid β protein deposition in the corpus striatum of patients with Alzheimer's disease
Author(s) -
Brilliant M. J.,
Elble R. J.,
Ghobrial M.,
Struble R. G.
Publication year - 1997
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1997.tb01302.x
Subject(s) - putamen , striatum , globus pallidus , pathology , amyloid (mycology) , alzheimer's disease , caudate nucleus , medicine , neuroscience , disease , basal ganglia , biology , central nervous system , dopamine
The distribution of amyloid β protein deposition in the corpus striatum of patients with Alzheimer's disease The distribution of amyloid β peptide (Aβ) was quantified in the corpus striatum and pallidum of 10 patients with Alzheimer's disease (AD) and three patients with both Alzheimer's disease and Parkinson's disease (AD–PD). Aβ occurred almost exclusively in plaques that did not have neurites or amyloid cores. Caudate, accumbens nuclei and rostral putamen contained more of the diffuse plaques than did caudal putamen. No diffuse plaques were found in the neighbouring globus pallidus. This distribution of Aβ deposition may reflect the distribution of diseased synaptic cortical afferents rather than a putative vascular source of Aβ.