Premium
First Alfred Meyer Memorial Lecture. Epileptic brain damage: a consequence and a cause of seizures[Note 1. Presented in memory of Alfred Meyer to the British ...]
Author(s) -
Meldrum B.
Publication year - 1997
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1997.tb01201.x
Subject(s) - anterior temporal lobectomy , hippocampus , neuroscience , epilepsy , lesion , limbic system , hippocampal sclerosis , psychology , medicine , temporal lobe , pathology , central nervous system
Alfred Meyer and his colleagues were the first to report (1954–1956) that the most frequent pathology in tissue from patients with complex partial seizures successfully treated by anterior temporal lobectomy is mesial temporal sclerosis, and that the majority of patients with this lesion give a history of a prolonged seizure early in life. These observations have been repeatedly confirmed. Experimental data from animal models strongly supports the hypothesis that a prolonged generalized or limbic seizure in early life damages the hippocampus and other limbic structures, facilitating an epileptogenic process that, after a latent period, gives rise to spontaneous limbic seizures. Some mechanisms potentially contributing to this process have been identified.