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Correlations between the morphology of diffuse and primitive β‐amyloid (Aβ) deposits and the frequency of associated cells in Down's syndrome
Author(s) -
Armstrong R. A.
Publication year - 1996
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1996.tb01131.x
Subject(s) - hippocampus , neuroglia , biology , staining , pathology , amyloid (mycology) , morphology (biology) , chemistry , anatomy , neuroscience , central nervous system , medicine , genetics
Correlations between the morphology of β‐amyloid (Aβ) deposits and the frequency with which they are associated with neurons and glial cells were studied in Down's syndrome. The diameter of diffuse deposits was positively correlated with the frequency of large (>25 μm) neuronal cell bodies in the isocortex and with glial cells in the hippocampus. Diameters of primitive deposits were positively correlated with glial cells in the hippocampus and with glial cells and neurons in the isocortex. Staining intensity was positively correlated with glial cells especially in the hippocampus. The data suggest that: (i) diffuse deposits develop from neurons and primitive deposits from glia; (ii) the size of Aβ deposits depends on the numbers of neurons and glia; (iii) glial cells are also involved in the conversion of Aβ to amyloid; and (iv) the increased density of primitive deposits in the hippocampus is determined by the high density of glial cells.