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Neurological reactions in HIV‐infected patients treated with trichosanthin
Author(s) -
Garcia P. A.,
Bredesen D. E.,
Vinters H. V.,
Einsiedel R. Graefin,
Williams R. L.,
Kahn J. O.,
Byers V. S.,
Levin A. S.,
Waites L. A.,
Messing R. O.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00461.x
Subject(s) - trichosanthin , asymptomatic , medicine , coma (optics) , pathological , immunology , human immunodeficiency virus (hiv) , pathology , virology , biology , physics , microbiology and biotechnology , optics
Trichosanthin is a ribosome‐inactivating protein that is being studied as a possible treatment for patients infected with human immunodeficiency virus (HIV). We report the clinical and pathological features in two patients who experienced neurological reactions to trichosanthin. Both patients were neurologically asymptomatic prior to treatment but developed coma and multifocal neurological deficits after treatment. Neuropathological examination revealed regions of severe, multifocal necrosis with histiocytic infiltrates. These reactions to trichosanthin may be mediated by soluble factors released by HIV‐infected macrophages.