Premium
Ependymal cells of the choroid plexus express tumour necrosis factor‐α 1
Author(s) -
Tarlow M. J.,
Jenkins R.,
Comis S. D.,
Osborne M. P.,
Stephensl S.,
Stanley P.,
Crocker J.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00447.x
Subject(s) - choroid plexus , ependymal cell , tumor necrosis factor alpha , cerebrospinal fluid , pathology , proinflammatory cytokine , necrosis , cytokine , in situ hybridization , biology , cytoplasm , immunocytochemistry , in vivo , microbiology and biotechnology , inflammation , medicine , immunohistochemistry , central nervous system , immunology , endocrinology , gene expression , biochemistry , gene
Tumour necrosis factor‐alpha (TNFa) is a major proinflammatory cytokine which appears in the cerebrospinal fluid very early after endotoxin challenge, and is likely to be produced locally. Following in vivo and in vitro challenge with endotoxin, we have demonstrated immunocytochemically and by in situ hybridization that pig and guinea‐pig choroid plexus ependymal cells can produce TNFa. Immuno‐electron microscopy shows that this protein is localized within ependymal cells to the cytoplasm and microvilli. We suggest that this TNFa may be important in the initiation of the inflammatory response in bacterial meningitis.