Premium
Differential pattern of β‐amyloid protein deposition within cortical sulci and gyri in Alzheimer's disease
Author(s) -
Clinton J.,
Roberts G. W.,
Gentleman S. M.,
Royston M. C.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00438.x
Subject(s) - cytoarchitecture , cortex (anatomy) , neuroscience , frontal cortex , temporal cortex , cerebral cortex , biology , alzheimer's disease , pathology , psychology , anatomy , disease , medicine
We have quantified the pattern of β‐amyloid protein (βAP) deposition in the sulci and gyri of the frontal cortex in Alzheimer's disease. The distribution pattern in the frontal cortex gyri is unequivocally different from the pattern found in the frontal sulci. These findings, in conjunction with our previous studies, reflect a differential vulnerability between the sulci and the gyri with respect to Alzheimer's disease pathology, sulci being affected to a greater extent. It is probable that the different patterns of deposition relate to the underlying cytoarchitecture of the cortex.