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Heterogeneity of centronuclear myopathy shown by flow cytometry of nuclear DNA
Author(s) -
Metze K.,
Schnabel R.,
Mellin W.,
Gullotta F.,
Hiddemann W.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00425.x
Subject(s) - nuclear dna , flow cytometry , myopathy , dna , pathology , ploidy , biology , microbiology and biotechnology , medicine , genetics , gene , mitochondrial dna
Determination of nuclear DNA by flow cytometry of skeletal muscle biopsies of three unrelated male patients with centronuclear (myotubular) myopathy demonstrated, in two patients, a normal pattern and, in one case, a near haploid DNA content in c. 60% of all nuclei, indicating muscle tissue mosaicism.