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Malignant infiltration of peripheral nerves in the course of acute myelomonoblastic leukaemia: neuropathological study of two cases
Author(s) -
Vital A.,
Vital C.,
Ellie E.,
Ferrer X.,
Lagueny A.,
Ferrer A. M.,
Broustet A.,
GbikpiBenissan G.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00422.x
Subject(s) - immunocytochemistry , pathology , infiltration (hvac) , peripheral , medicine , biopsy , peripheral nerve , axonal degeneration , anatomy , physics , thermodynamics
Two patients suffering from acute myelomonoblastic leukaemia developed clinical evidence of peripheral nerve involvement. In both cases, a peripheral nerve biopsy revealed endoneurial cellular infiltrates which were identified as leukaemic cells by immunocytochemistry. Ultrastructural studies showed mainly axonal damage. Moreover, in one patient, a few features of active demyelination were also observed.