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Histochemical and immunocytochemical study of ubiquitinated neuronal inclusions in amyotrophic lateral sclerosis
Author(s) -
Mather K.,
Martin J. E.,
Swash M.,
Vowles G.,
Brown A.,
Leigh P. N.
Publication year - 1993
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1993.tb00419.x
Subject(s) - amyotrophic lateral sclerosis , immunocytochemistry , cytoplasmic inclusion , anterior horn cell , pathology , ubiquitin , neuroscience , biology , abnormality , cytoplasm , degenerative disease , disease , anatomy , medicine , microbiology and biotechnology , biochemistry , gene , psychiatry
Ubiquinated cytoplasmic inclusions are a characteristic feature of the anterior horn cell pathology of amyotrophic lateral sclerosis. The underlying abnormality leading to the production of these inclusions in this neurodegenerative motor system disease is unknown. Despite the application of a wide range of histochemical and immunocytochemical techniques we have been unable to identify a core constituent protein in these intraneuronal inclusions. A novel approach to this problem is required.