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Allocortical involvement in Huntington's disease
Author(s) -
BRAAK H.,
BRAAK E.
Publication year - 1992
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1992.tb00824.x
Subject(s) - lipofuscin , subiculum , nissl body , entorhinal cortex , pathology , nerve cells , disease , biology , medicine , neuroscience , hippocampus , staining , microbiology and biotechnology , dentate gyrus
Seven brains of individuals who had suffered from Huntington's disease and seven control brains were examined. Preparations stained for Nissl material and lipofuscin pigment revealed a characteristic layer‐specific loss of nerve cells in two allocortical areas, the entorhinal region and the subiculum. The most severe changes occurred in the entorhinal layer Pri‐y while layer Pre‐a, layer Pre‐y and the subiculum showed less severe alterations.