Premium
Ectopic intrapelvic medulloepithelioma: case Report
Author(s) -
FIGARELLABRANGER D.,
GAMBARELLI D.,
PEREZCASTILLO M.,
GENTET J. C.,
GRISOLI F.,
PELLISSIER J. F.
Publication year - 1992
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1992.tb00802.x
Subject(s) - pathology , ependymal cell , cytokeratin , glial fibrillary acidic protein , basal lamina , ependyma , biology , enolase , vimentin , anatomy , epithelium , immunohistochemistry , medicine , ultrastructure , central nervous system , neuroscience
A primary extraspinal medulloepithelioma with lung metastases is Reported. The tumour was located in the presacral area. Microscopically, it showed typical features of medulloepithelioma with focal ependymal differentiation. Medulloepitheliomas are maligant tumours of primitive neuro‐epithelium usually involving the cerebral hemispheres. This Report demonstrates their possible extraspinal presacral occurrence. By immunohistochemistry, neuron‐specific‐enolase, S100 protein, vimentin, cytokeratin and glial fibrillary acidic protein were found in some tumour cells. Electron microscopy demonstrated poorly differentiated cells forming stratified epithelium resting on a basal lamina and short functional complexes at the apical pole. Ultra‐structural evidence of ependymal differentiation was observed. Presario medulloepithelioma may arise from undifferentiated embryonic cells forming the Presario remnants of the neurenteric canal.