Premium
The number and mean volume of neurons in the cerebral cortex of rats intoxicated with acrylamide
Author(s) -
TANDRUP T.,
BRENDGAARD H.
Publication year - 1992
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1992.tb00787.x
Subject(s) - neocortex , acrylamide , cerebral cortex , intraperitoneal injection , cortex (anatomy) , chemistry , endocrinology , anesthesia , medicine , neuroscience , biology , organic chemistry , copolymer , polymer
Acrylamide was given in an accumulated dose of 500 mg/kg to rats by intraperitoneal injection in two different dosing schedules: 50 mg/kg twice a week for 5 weeks and 33.3 mg/kg twice a week for 7.5 weeks. The effect of acrylamide intoxication on the neurons in the cerebral cortex of the rat was studied using unbiased stereological methods. A reduction of brain weight of 8% was seen in both the intoxicated groups. The volume of neocortex was significantly decreased in the experimental groups, but the density of neurons was increased resulting in an unchanged total number of neurons. The mean volume of neurons in neocortex was significantly decreased in both acrylamide intoxicated groups. There was no difference between the two different intoxication schedules. The possibility that acrylamide causes neuronal death and the effect of eventual differential cellular sensitivity is discussed.