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Immunocytochemical localization of ubiquitin at human neuromuscular junctions
Author(s) -
SERDAROGLU P.,
ASKANAS V.,
ENGEL W. K.
Publication year - 1992
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1992.tb00785.x
Subject(s) - ubiquitin , neuromuscular junction , acetylcholine receptor , polyclonal antibodies , microbiology and biotechnology , immunoprecipitation , monoclonal antibody , biology , ubiquitin ligase , receptor , antibody , chemistry , neuroscience , biochemistry , immunology , gene
Using several specific monoclonal and polyclonal antibodies, we found that ubiquitin is highly concentrated in the post‐synaptic domain of human neuromuscular junctions. The distribution and pattern of ubiquitin immunoreactivity is identical to the localization of bound a‐bungarotoxin, suggesting that ubiquitin may be involved in post‐translational modification or turnover of the acetylcholine receptor or other junctional proteins of the muscle fibre.