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Distribution of Alzheimer's disease amyloid protein precursor in normal human and rat nervous system
Author(s) -
CORIA F.,
MORENO A.,
TORRES A.,
AHMAD I.,
GHISO J.
Publication year - 1992
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1992.tb00762.x
Subject(s) - alzheimer's disease , distribution (mathematics) , amyloid (mycology) , pathology , central nervous system , nervous system , disease , neuroscience , amyloid precursor protein , medicine , biology , mathematical analysis , mathematics
Alzheimer's disease and cerebral amyloid angiopathies (CAA) are clinically heterogeneous diseases, but pathogenically related by the deposition of βA4‐amyloid in the brain in the form of neuritic plaques and/or vascular infiltrates. Antibodies directe against the N‐terminal region of the predicted sequence of the βA4 amyloid protein precursor (APP) were used to investigate the cellular distribution of this protein in the brain of normal humans and rats. We found a widespread presence of APP throughout the nervous tissue, including neurons, blood vessels, menigeal membranes, choroid plexus and ependymal cells. The highest APP immunoreactivity in both species was found in neuronal cell bodies and their processes, and around blood vessels. These findings may account for the clinical, pathological and aetiological differences found among the βA4‐amyloidosis.