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Glioblastoma multiforme of the hippocampus in advanced Alzheimer's disease
Author(s) -
POOLE E. C.,
KEPES J. J.
Publication year - 1991
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1991.tb00753.x
Subject(s) - gliosis , autopsy , hippocampus , pathology , disease , glioblastoma , medicine , alzheimer's disease , central nervous system disease , cancer research
An 87‐year‐old woman suffered from Alzheimer's disease diagnosed 6 years prior to her death. Autopsy showed in addition to far‐advanced Alzheimer's disease, a large, partially necrotic glioblastoma occupying her right hippocampus. Occurrence of a glial neoplasm in Alzheimer's disease could well be coincidental, since both entities are fairly common in elderly individuals; it is however, uncommon for gliomas to centre on the hippocampus itself. For these reasons it is possible (although cannot be proven from a single case), that florid reactive gliosis commonly associated with Alzheimer's disease, may have played a role in eventually initiating neoplastic proliferation of astrocytes in this patient.