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B and T lymphocytes are affected in lysosomal disorders – an immunoelectron microscopic study
Author(s) -
BRUCK W.,
GOEBEL H. H.,
DIENES P.
Publication year - 1991
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1991.tb00717.x
Subject(s) - immunoelectron microscopy , neuronal ceroid lipofuscinosis , pathology , lipofuscin , lysosomal storage disease , organelle , biology , lysosome , glucocerebrosidase , disease , medicine , immunohistochemistry , microbiology and biotechnology , enzyme , biochemistry
Circulating lymphocytes of four patients with mucopolysaccharidoses II and IIIA, four patients with juvenile neuronal ceroid‐lipofuscinosis, one patient each with glycogenosis type II, infantile neuronal ceroid‐lipofuscinosis, and Gaucher disease were classified by immunoelectron microscopy as B or T lymphocytes. Disease‐specific lyosomal inclusions as well as non‐specific lysosomal organelles, especially Gall bodies were identified in B and T lymphocytes. These non‐quantitative studies indicate that both B and T lymphocytes participate in the lysosomal storage process.