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Distribution of neurofibrillary tangle formation and [ 3 H]‐D‐aspartate receptor binding in the thalamus in the normal elderly brain, in Alzheimer's disease and in Parkinson's disease
Author(s) -
XUEREB J. H.,
CANDY J. M.,
PERRY E. K.,
PERRY R. H.,
MARSHALL E.,
BONHAM J. R.
Publication year - 1990
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1990.tb01287.x
Subject(s) - tangle , neurofibrillary tangle , glutamatergic , thalamus , neuroscience , alzheimer's disease , neurodegeneration , disease , parkinson's disease , degenerative disease , pathology , biology , medicine , central nervous system disease , glutamate receptor , receptor , senile plaques , mathematics , pure mathematics
The overactivity of glutamatergic neurons may underlie some neurodegenerative disorders, including Alzheimer's disease (AD). We explored the relationship between glutamatergic transmission and neurofibrillary tangle formation by measuring [ 3 H]‐D‐aspartate binding activity and the proportion of neurons containing tangles within individual thalamic nuclei in five AD cases. Five elderly normal and five Parkinson's disease (PD) cases were used as controls. A highly significant correlation between [ 3 H]‐D‐aspartate binding and tangle counts in Alzheimer's disease suggests that those thalamic nuclei which normally receive a relatively dense glutamatergic afferent input are predisposed to tangle formation. There were no significant differences in individual thalamic nuclear [ 3 H]‐D‐aspartate binding between controls and the AD and PD groups.