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ENHANCEMENT OF DEMYELINATION IN THE CENTRAL NERVOUS SYSTEM OF SEMLIKI FOREST VIRUS INFECTED MICE AFTER PRETREATMENT WITH MURAMYL DIPEPTIDE
Author(s) -
ILLAVIA S. J.,
WEBB H. E.,
COLOVER J.
Publication year - 1988
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1988.tb01339.x
Subject(s) - semliki forest virus , muramyl dipeptide , ovalbumin , encephalomyelitis , virus , virology , central nervous system , immunology , biology , immune system , neuroscience , biochemistry , rna , gene
Illavia S. J., Webb H. E. & Colover J. (1988) Neuropathology and Applied Neurobiology 14, 483–493 Enhancement of demyelination in the central nervous system of Semliki Forest virus infected mice after pretreatment with muramyl dipeptide Semliki Forest virus infections in mice produce an encephalitis with demyelination. If before giving the virus the mice are treated with muramyl dipeptide in Freund's incomplete adjuvant, there is a significant increase in demyelination. If ovalbumin is added to the above and then followed after an interval by a second dose of ovalbumin and finally by the virus, the demyelination is further, but only marginally increased. The addition of ovalbumin without muramyl dipeptide in the schedule appears to increase the number of infiltrating cells and to a lesser extent the perivascular cuffing, but does not increase the demyelination as compared to that obtained when Semliki Forest virus is given on its own.