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NECROTIZING VASCULITIS OF THE NERVOUS SYSTEM IN A PATIENT WITH AIDS–RELATED COMPLEX
Author(s) -
VINTERS H. V.,
GUERRA W. F.,
EPPOLITO L.,
III P. E. KEITH
Publication year - 1988
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1988.tb01142.x
Subject(s) - vasculitis , medicine , fulminant , pathology , necrotizing vasculitis , myelopathy , etiology , nervous system , spinal cord , cerebral vasculitis , central nervous system , immunology , disease , psychiatry
Necrotizing vasculitis of the nervous system in a patient with AIDS‐related complex A patient with AIDS‐related complex (ARC) presented with a fulminant neurologic syndrome suggestive of ascending myelopathy, and died approximately 48 h after admission to hospital. At necropsy, there was evidence of a severe necrotizing vasculitis affecting the nervous system most severely, with multifocal haemorrhagic necroses of the spinal cord and cauda equina. Although a rare intranuclear inclusion suggestive of herpesvirus infection was seen in the predominantly lympho‐histiocytic infiltrate in and around blood vessel walls, the precise aetiology of the angiitis was not apparent. It may represent a response to AIDS virus infection of one or more components of the blood vessel wall.