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THE TOXICITY AND NEUROPATHOLOGY OF DIMETHYLETHYLTIN AND METHYLDIETHYLTIN IN RATS
Author(s) -
ALDRIDGE W. N.,
VERSCHOYLE R. D.,
THOMPSON CAROL A.,
BROWN A. W.
Publication year - 1987
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1987.tb00170.x
Subject(s) - chromatolysis , myelin , toxicity , chemistry , hippocampal formation , neuropathology , myelin sheath , neurotoxicity , central nervous system , anatomy , toxicology , biochemistry , pharmacology , neuroscience , pathology , biology , medicine , spinal cord , disease , organic chemistry
Triethyltin causes an increase in brain water with vacuolation of myelin sheaths, whereas trimethyltin is selectively damaging to neurons, especially of the hippocampal formations, causing chromatolysis, accumulation of cytoplasmic dense bodies and often cell death. The effects on rats of the analogues, dimethylethyltin and methyldiethyltin (oral LD 50 14mg/kg and 7.5–10.0 mg/kg respectively) are now reported. The dimethylethyl compound produces functional changes resembling those caused by trimethyltin, while the methyldiethyl compound causes responses similar to those produced by triethyltin. Structurally, however, the dimethylethyl compound, while producing marked nerve cell changes of the trimethyltin type also causes moderate vacuolation of myelin sheaths. By contrast, methyldiethyltin causes marked vacuolation of myelin sheaths of the triethyltin type and relatively minor neuronal changes of the trimethyltin type. These findings are discussed in terms of the structure‐activity relationships of trialkyltin compounds.