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DO HUMAN T‐LYMPHOTROPHIC VIRUSES (HTLVs) AND OTHER ENVELOPED VIRUSES INDUCE AUTOIMMUNITY IN MULTIPLE SCLEROSIS?
Author(s) -
DALGLEISH A. G.,
FAZAKERLEY J. K.,
WEBB H. E.
Publication year - 1987
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1987.tb00064.x
Subject(s) - multiple sclerosis , virology , immunology , viral envelope , autoimmunity , pathogenesis , virus , antigen , biology , myelin , myelin basic protein , antibody , central nervous system , neuroscience
A virally induced autoimmune reaction may be important in the pathogenesis of multiple sclerosis. The role that glycolipids and myelin basic protein presented to the virus may play in this process is considered. The most likely cells to be the source of autoantigens are neurons, myelin and oligodendrocytes. Viral infection of class II‐expressing cells and association of the viral envelope autoantigens and the class II molecules could trigger an autoimmune reaction. It is suggested that for MS to develop following a virus infection the virus will need to cause expression of class II antigens on brain cells as well as fulfill the same role as an antigen presenting cell. The part which T‐lymphotrophic viruses (HTLVs) and other enveloped viruses may play in this phenomenon is discussed.