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LEIGH'S DISEASE ‐SEVERAL NOSOLOGICAL ENTITIES WITH AN IDENTICAL HISTOPATHOLOGICAL COMPLEX?
Author(s) -
WALTER G. F.,
BRUCHER J. M.,
MARTIN J. J.,
CEUTERICK C.,
PILZ P.,
FREUND M.
Publication year - 1986
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1986.tb00683.x
Subject(s) - disease , pathology , medicine , biology
Although Leigh's disease corresponds to a quite distinct histopathological complex, clinical and biochemical findings may be very divergent. By the description of classical and borderline cases and by the comparison with cases from the literature, it is suggested that Leigh's disease encompasses several nosological entities related to different disorders of the energy metabolism. They produce an identical histopathological complex. New evidence for a cerebral mitochondriopathy is also given.