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EFFECTS OF PRENATAL EXPOSURE TO ETHANOL ON THE MATURATION OF THE PYRAMIDAL NEURONS IN THE CEREBRAL CORTEX OF THE GUINEA‐PIG: A QUANTITATIVE GOLGI STUDY
Author(s) -
FABREGUES I.,
FERRER I.,
GAIRI J. M.,
CAHUANA A.,
GINER P.
Publication year - 1985
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1985.tb00026.x
Subject(s) - dendritic spine , cerebral cortex , dendrite (mathematics) , apical dendrite , somatosensory system , guinea pig , cortex (anatomy) , golgi apparatus , anatomy , neuroscience , biology , synapse , endocrinology , hippocampal formation , microbiology and biotechnology , endoplasmic reticulum , geometry , mathematics
Fabregues I., Ferrer I., Gairi J. M., Cahuana A. & Giner P. (1985) Neuropathology and Applied Neurobiology 11, 291–298 Effects of prenatal exposure to ethanol on the maturation of the pyramidal neurons in the cerebral cortex of the guinea‐pig: a quantitative golgi study The effects of chronic ethanol consumption during gestation on the development of layer V pyramidal cells was studied quantitatively in the somatosensory cerebral cortex of the newborn guinea‐pig. The spread of the basilar dendritic arborizations and counts of dendritic spines on the apical dendrite of neurons that had been processed with the rapid Golgi method were compared with those found in age‐matched controls receiving an isocaloric diet without alcohol. There were significant differences in the number of primary basilar dendrites ( P < 005) and dendritic ramifications at a distance of 25 μM from the soma (P < 0.01) between the alcohol‐exposed and control animals. There also were significant differences in the number of dendritic spines on the apical dendrite ( P < 0.001). This experimental model further illustrates developmental anomalies in the cerebral cortex following prenatal ethanol exposure.