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A QUANTITATIVE HISTOLOGICAL STUDY OF NEURONAL LOSS FROM THE LOCUS COERULEUS OF AGEING MICE
Author(s) -
STURROCK R. R.,
RAO K. A.
Publication year - 1985
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1985.tb00004.x
Subject(s) - locus coeruleus , ageing , neuron , pathology , medicine , biology , physiology , anatomy , endocrinology , central nervous system , neuroscience
A quantitative histological study of neurons in the locus coeruleus (LC) was carried out in ASH/TO mice aged 6, 9, 12, 15, 22, 25, 28 and 31 months. Counts were carried out on the right LC in 6 /xm parasagittal sections. There was a wide individual variation and also a variation between age groups from 6 and 15 months, but the mean number of neurons in the LC never fell below 1325 until after 25 months. The mean number of neurons in the LC from 6 to 25 months was 1520 ± 73. The mean number of neurons at 28 and 31 months was 1009 ± 60 and 854 ± 146 respectively. This indicates that the pattern of neuron loss in the LC of ASH/TO mice is similar to that found in the normal ageing human brain in a number of quantitative histological studies.