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A GOLGI STUDY OF CEREBELLAR ATROPHY IN HUMAN CHRONIC ALCOHOLISM
Author(s) -
FERRER I.,
FABREGUES I.,
PINEDA M.,
GRACIA I.,
RIBALTA T.
Publication year - 1984
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1984.tb00357.x
Subject(s) - cerebellar vermis , purkinje cell , cerebellum , atrophy , golgi apparatus , cerebellar cortex , degeneration (medical) , biology , neuroscience , anatomy , pathology , medicine , cell , genetics
When processed by the rapid Golgi method, a significant reduction ( P < 0402) of the dendritic arborization of Purkinje cells located at the tips of the folia of the rostral vermis was demonstrated in four human cases of cerebellar atrophy, related to chronic alcohol consumption. Except for isolated damaged Purkinje cells located on the depth of the sulci of the rostral vermis in all but one case, no significant differences were observed between alcoholic cases and controls of comparable ages among Purkinje cells located in the remainder of the vermis or the cerebellar hemispheres. These results suggest that structural changes, which precede neuronal death and cell loss, are present in Purkinje cells of the rostral vermis in human cerebellar alcoholic degeneration.