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IN‐SITU CHARACTERIZATION OF MONONUCLEAR CELL INFILTRATES IN LESIONS OF MULTIPLE SCLEROSIS
Author(s) -
NYLAND HARALD,
MÖRK SVERRE,
MATRE ROALD
Publication year - 1982
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1982.tb00308.x
Subject(s) - peripheral blood mononuclear cell , multiple sclerosis , pathology , receptor , lymphocyte , neuropathology , mononuclear cell infiltration , medicine , macrophage , immunology , biology , in vitro , biochemistry , disease
Nyland H, Mork S & Matre R.1982 Neuropathology and Applied Neurobiology 8, 403–411 In‐situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis The mononuclear cell infiltrates in autopsy material from brains and spinal cords of six patients with multiple sclerosis (MS) were characterized in situ. Receptors for sheep erythrocytes and anti‐T lymphocyte serum were used to identify T lymphocytes. Receptors for the activated third components of complement and for the Fc‐portion of IgG (Fey receptors) were used as markers for macrophages and lymphocytes. In acute and recent MS lesions, perivascular infiltrates of mononuclear cells were commonly found. Most cells were T lymphocytes. Some B lymphocytes were also demonstrated. The demyelinating lesions contained large numbers of lipid macrophages expressing Fey receptors. The lipid macrophages are probably derived from microglial cells. The chronic, demyelinated lesions contain a few mononuclear cells, mainly B lymphocytes and plasma cells.