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DEMYELINATION INDUCED IN MICE BY AVIRULENT SEMLIKI FOREST VIRUS. I. VIROLOGY AND EFFECTS ON OPTIC NERVE
Author(s) -
ILLAVIA SHIRIN J.,
WEBB H. E.,
PATHAK SNEHLATA
Publication year - 1982
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1982.tb00255.x
Subject(s) - semliki forest virus , optic nerve , retina , virus , virology , neuropathology , biology , pathology , medicine , anatomy , neuroscience , rna , disease , biochemistry , gene
Illavia S.J., Webb H.E. & Pathak S. (1982) Neuropathology and Applied Neurobiology 8, 35–42 Demyelination induced in mice by avirulent Semliki Forest virus. I. Virology and effects on optic nerve wiss A 2 G mice were infected intraperitoneally with an avirulent strain of Semliki Forest virus. The virus titres in the optic nerves, retina and brain were estimated on post‐inoculation days 3 to 8. High titres of virus were obtained in the optic nerve, retina and brain. The optic nerves, retina and brain were studied by light microscopy up to post‐inoculation day 67. Electron microscope studies were carried out on the optic nerve on post‐inoculation days 11 and 14. Inflammatory, microcystic changes and demyelination seen in the optic nerve were similar to those found in the central nervous system.