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REGIONAL NEURONE DAMAGE AFTER CEREBRAL ISCHAEMIA IN THE NORMO‐ AND HYPOGLYCAEMIC RAT
Author(s) -
DIEMER N. H.,
SIEMKOWICZ E.
Publication year - 1981
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1981.tb00091.x
Subject(s) - ischemia , medicine , hippocampal formation , brain damage , cerebral infarction , infarction , anesthesia , endocrinology , cardiology , myocardial infarction
Ten minutes of total cerebral ischaemia was produced in normo‐ and hypoglycaemic rats. The most conspicuous findings were loss of hippocampal (CA‐1) pyramidal cells and Purkinje cells, which were most pronounced in the normoglycaemic rats. While pre‐ischaemic hypoglycaemia to some extent protected these cells, it led to infarction or severe ischaemic nerve cell changes in the brain stem nuclei and lowered the neurological restitution of the hypoglycaemic animals. The regional damage in these rats, which were kept normotensive after ischaemia, was not due to circulatory insufficiency. However, rats with untreated spontaneous low blood pressure in the early postischaemic period showed multiple small infarcts.