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PATHOLOGY OF DISULFIRAM NEUROPATHY
Author(s) -
BOULDIN T. W.,
HALL C. D.,
KRIGMAN M. R.
Publication year - 1980
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1980.tb00286.x
Subject(s) - disulfiram , neuropathology , wallerian degeneration , sural nerve , pathological , remyelination , medicine , peripheral neuropathy , pathology , nerve biopsy , myelin , central nervous system , endocrinology , pharmacology , disease , diabetes mellitus
Bouldin T.W., Hall CD & Krigman M.R.1980 Neuropathology and Applied Neurobiology 6, 155–160 Case report. Pathology of disulfiram neuropathy The pathological changes in a sural nerve biopsy from a 42‐year‐old woman with disulfiram‐induced peripheral neuropathy were assessed by quantitative light microscopy, electron microscopy, and the study of teased nerve fibres. The nerve had a marked loss of myelinated fibres; of the remaining myelinated fibres some were undergoing Wallerian‐type axonal degeneration. Large myelinated fibres were preferentially involved. Primary demyelination, remyelination, and evidence of regeneration were not present. Because of the marked differences between the pathological findings in disulfiram neuropathy and carbon disulfide neuropathy, it is concluded that carbon disulfide is not responsible for the neurotoxic effect of disulfiram.