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VASOACTIVE INTESTINAL POLYPEPTIDE IN THE PITUITARY PARS NERVOSA
Author(s) -
NOORDEN SUSAN VAN,
POLAK JULIA M.,
BLOOM S. R.,
BRYANT M. G.
Publication year - 1979
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1979.tb00667.x
Subject(s) - vasoactive intestinal peptide , neuropeptide , radioimmunoassay , immunocytochemistry , hypothalamus , vasopressin , endocrinology , medicine , vasoactive , peptide hormone , neuropeptide y receptor , biology , hormone , receptor
Van Noorden S., Polak J.M., Bloom S.R. & Bryant M.G. (1979) Neuropathology and Applied Neurobiology 5, 149–153 Vasoactive intestinal polypeptide in the pituitary pars nervosa Vasoactive intestinal polypeptide (VIP) is a widely distributed neuropeptide which has recently been found in the hypothalamus and in hypothalamo‐hypophyseal portal blood. We have examined the pituitary of several mammalian species for the presence of VIP by immunocytochemistry and radioimmunoassay and report here that the pars nervosa contains a considerable quantity of VIP (100–250 fmol/ mg) which, in the dog, can be shown to be present in nerve fibres. It is possible that neurohypophyseal VIP may be a local releasing agent for vasopressin.