Premium
VACUOLATION IN THE HUMAN CEREBRAL CORTEX AND ITS RELATIONSHIP TO THE INTERVAL BETWEEN DEATH AND AUTOPSY AND TO SYNAPSE NUMBERS: AN ELECTRONMICROSCOPIC STUDY
Author(s) -
GIBSON P. H.,
TOMLINSON B. E.
Publication year - 1979
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1979.tb00608.x
Subject(s) - neuropathology , autopsy , cerebral cortex , cortex (anatomy) , electron micrographs , synapse , postmortem changes , pathology , programmed cell death , pyramidal cell , abnormality , anatomy , neuroscience , hippocampus , biology , medicine , electron microscope , apoptosis , biochemistry , physics , disease , optics , psychiatry
Gibson P.H. & Tomlinson B.E. (1979) Neuropathology and Applied Neurobiology 5 , 1–7 Vacuolation in the human cerebral cortex and its relationship to the interval between death and autopsy and to synapse numbers: an electron microscopic study Vacuolation in the human cerebral cortex resulting from swelling of cell processes after death was measured in electron micrographs in material obtained up to 69 hours post mortem from subjects with no known neurological abnormality. Vacuolation was found to increase significantly up to 30–35 hours after death and then to decrease. Accompanying this change was a significant reduction in the numbers of recognizable synapses which probably resulted from compression due to the vacuolation rather than from post‐mortem disintegration.