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AN IMMUNOFLUORESCENCE STUDY OF THE PASSIVE ARTHUS REACTION IN RAT SCIATIC NERVE
Author(s) -
RIDLEY A.,
RAINBIRD SUSAN
Publication year - 1978
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1978.tb00539.x
Subject(s) - arthus reaction , immunofluorescence , fluorescein isothiocyanate , antibody , sciatic nerve , antigen , immune reaction , fluorescein , direct fluorescent antibody , immunology , chemistry , isothiocyanate , pathology , medicine , anatomy , fluorescence , biochemistry , physics , quantum mechanics
The Arthus reaction, passively induced in rat sciatic nerve by local injection of antibody and intravenous injection of antigen, was studied by immunofluore‐scence, using fluorescein and tetramethylrhodamine isothiocyanate. The reaction in nerve is similar to that occurring in skin. Antigen‐antibody complexes formed at the site of the reaction activate complement and attract large numbers of poly‐morphonuclear leucocytes which then ingest the immune complexes. The significance of the Arthus reaction in relation to diseases of the peripheral nervous system is mentioned.