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MULTIPLE SCLEROSIS AND EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS: SPECIFIC DEMYELINATION OF CNS IN CULTURE
Author(s) -
BORNSTEIN M. B.,
RAINE C. S.
Publication year - 1977
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1977.tb00596.x
Subject(s) - encephalomyelitis , multiple sclerosis , myelin , central nervous system , spinal cord , medicine , immunology , pathology , freund's adjuvant , experimental autoimmune encephalomyelitis , adjuvant , psychiatry
Multiple sclerosis and experimental allergic encephalomyelitis: specific demyelination of CNS in culture Cultures of mouse spinal cord tissue coupled to dorsal root ganglia, in which both CNS and PNS myelin develop, have been exposed for various periods of time to sera from patients with multiple sclerosis (MS) and animals with experimental allergic encephalomyelitis (EAE) induced by inoculation with whole CNS tissue in complete Freund's adjuvant. In both instances (MS and EAE), there was a selective depletion of CNS myelin with no adverse effect visible on PNS myelin in the same cultures. Prolonged exposure to demyelinating sera led to a sclerotic appearance in the CNS portion of cultures while PNS myelination progressed unimpeded. The results lend weight to the hypothesis that MS results from an immunological mechanism directed specifically against the CNS.