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POLYNEUROPATHIES AND CNS PROTEIN METABOLISM. I. DESCRIPTION OF THE ACRYLAMIDE SYNDROME IN RATS
Author(s) -
GIPON L.,
SCHOTMAN P.,
JENNEKENS F. G. I.,
GISPEN W. H.
Publication year - 1977
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1977.tb00575.x
Subject(s) - acrylamide , open field , food consumption , metabolism , weight loss , body weight , food intake , endocrinology , physiology , medicine , chemistry , obesity , organic chemistry , agricultural economics , economics , copolymer , polymer
Behavioural, histological and metabolic studies were performed on acrylamide‐intoxicated rats. Treated rats showed disturbed food and water consumption accompanied by loss of body weight. In addition, in an open field test they displayed less ambulation and rearing activity than controls, and had severe difficulties in balancing on a rotating rod. The last test gives a reliable indication of the acryla‐mide‐induced disorder before the onset of histological changes. In the discussion it is suggested that the data question the neurotoxic selectivity of acrylamide.