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PEROXIDASE ACTIVITY IN THE PAROTID GLAND IN JUVENILE NEURONAL CEROID‐LIPOFUSCINOSIS
Author(s) -
PILZ H.,
GOEBEL H. H.
Publication year - 1977
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1977.tb00573.x
Subject(s) - peroxidase , lipofuscin , pathological , biology , parotid gland , isozyme , pathology , neuronal ceroid lipofuscinosis , cytochemistry , juvenile , enzyme , endocrinology , disease , medicine , biochemistry , genetics
The parotid gland of a 17 year old boy who died from juvenile type of neuronal ceroid‐lipofuscinosis contained autofluorescent lipopigments in epithelial and mesenchymal cells that showed the typical curvilinear and fingerprint profiles; these were not mixed with his secretory granules of the epithelial cells. Determination of p ‐phenylenediamine‐mediated peroxidase in this tissue under various conditions yieded normal total enzyme activity and isoenzyme pattern. From these findings it is concluded that the pathological changes in this inherited disease cannot be related to a peroxidase deficiency.