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THE EFFECTS OF MITOMYCIN C ON THE PROCESS OF REGENERATION IN THE MAMMALIAN PERIPHERAL NERVOUS SYSTEM
Author(s) -
HALL SUSAN M.,
GREGSON N. A.
Publication year - 1977
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1977.tb00570.x
Subject(s) - myelin , regeneration (biology) , schwann cell , mitomycin c , peripheral nervous system , cell division , peripheral , peripheral nerve , biology , cell , microbiology and biotechnology , central nervous system , anatomy , pathology , neuroscience , medicine , biochemistry , genetics
Schwann cell proliferation is a prominent feature of the normal response of a peripheral nerve fibre bundle to injury. In this report we have attempted to analyse the consequence of inhibiting this response using the cross‐linking alkylating agent mitomycin C. In the presence of the drug, Schwann cell division was inhibited within a region about the site of injection. In this region myelin breakdown was delayed relative to that occurring distally and in control fibres: even after 3 weeks many Schwann cells had failed to phagocytose their myelin. Regeneration subsequently took place—certain morphological features of the repaired mitomycin C‐treated zones are discussed. It is concluded that dilution of debris by successive Schwann cell divisions is necessary during the cellular response to injury in a peripheral nerve fibre bundle.