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ACCUMULATIONS OF NOR‐ADRENALINE ASSOCIATED WITH AXONAL CHANGES IN AUTONOMIC GANGLIA IN GRASS SICKNESS
Author(s) -
GILMOUR J. S.
Publication year - 1976
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1976.tb00512.x
Subject(s) - lesion , neurotoxin , adrenergic , catecholamine , pathology , anatomy , medicine , biology , receptor
Stellate ganglia from cases of grass sickness and control horses were examined, using the formaldehyde‐induced fluorescence method, for the presence of catecholamines. Accumulations of a catecholamine, identified as nor‐adrenaline, were observed in nerve fibre tracts within ganglia of horses with grass sickness. On the grounds of site and morphology these accumulations conform with axonal lesions seen in silver‐stained sections. The changes were compared with the results of experimental trauma to adrenergic nerves, and it was deduced that there is a primary axonal lesion in grass sickness. It was further suggested that this lesion may be caused by the neurotoxin already implicated in the disease.