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ASTROCYTE MITOSES AND ALZHEIMER TYPE I AND II ASTROCYTES IN ANOXIC ENCEPHALOPATHY
Author(s) -
DIEMER N. H.,
KLINKEN L.
Publication year - 1976
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1976.tb00505.x
Subject(s) - astrocyte , mitosis , biology , metaphase , microbiology and biotechnology , pathology , neuroscience , central nervous system , genetics , medicine , chromosome , gene
Astrocyte mitoses and Alzheimer type I and I1 astrocytes in anoxic en‐cephalopathy Numerous astrocyte mitoses, arrested in metaphase, were found in a case of anoxic encephalopathy. The number of chromosomes was not excessive, but in most the mitotic spindles appeared absent. Many Alzheimer type I and II astrocytes were also seen, together with a few cells containing both micronuclei and free chromosomes. The occurrence of such transitional forms supports the hypothesis that astrocyte mitoses arrested in metaphase constitute an intermediate stage in the formation of the tetraploid Alzheimer type I astrocytes from cells of Alzheimer type II.