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EXPERIMENTAL LEAD ENCEPHALOPATHY OF CALVES. HISTOLOGICAL OBSERVATIONS ON THE NATURE AND DISTRIBUTION OF THE LESIONS
Author(s) -
WELLS G. A. H.,
HOWELL J. MCC.,
GOPINATH C.
Publication year - 1976
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1976.tb00495.x
Subject(s) - neuropil , encephalopathy , pathology , pathological , lead acetate , necrosis , medicine , brain damage , cortex (anatomy) , biology , central nervous system , toxicity , neuroscience
Experimental lead encephalopathy of calves. Histological observations on the nature and distribution of the lesions Neurological signs were induced in four calves by the daily administration of 20 mg/kg body weight lead acetate. The time of onset and duration of symptoms varied, and the severity progressed to an acute neurological episode in three calves. Histological lesions in the brains of three calves consisted of focal vacuolation of the neuropil, neuronal necrosis and changes in capillary walls. These changes occurred in the cerebral cortex and in certain grey centres of the brain stem. The encephalopathy was associated with elevated blood and tissue lead levels, but could not be correlated with pathological effects in other organs. The nature of the lesions suggests a basic change in transport mechanisms between the blood and brain.