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NEUROFIBILARY DEGENERATION INDUCED IN THE RABBIT BY ALUMINUM CHLORIDE: ALUMINIUM NEUROFIBRILLARY TANGLES
Author(s) -
YATES CELIA. M.,
GORDON A.,
WILSON HELEN
Publication year - 1976
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1976.tb00491.x
Subject(s) - neurofibrillary tangle , pathology , chemistry , lesion , senile plaques , tangle , aluminium chloride , staining , alzheimer's disease , anatomy , aluminium , medicine , disease , mathematics , organic chemistry , pure mathematics
Neurofibrillary degeneration induced in the rabbit by aluminium chloride aluminium neurofibrillary tangles Neurofibrillary tangles were produced in the brain and spinal cord of rabbits by the intraventricular administration of aluminium chloride. The development of the tangles and of the accompanying behavioural effects was followed. The presence of tangles consistently preceded the onset of behavioural effects which comprised impairment of motor activity, terminal convulsions and opisthotonos. Limited electroencephalographic studies suggested that the convulsions were not of cortical origin. The lesion consisted of massed intraneuronal argyrophilic tangles which appeared as cytoplasmic clearings in sections stained with haematoxylin and eosin. The size of the tangle and the number of affected neurons increased with time and the tangles themselves were rather larger and differed in their distribution from those found in senile dementia and Alzheimer's disease. Of note was the sparing of the vagal nuclei and contrasting sensitivity of the hypoglossal nuclei to aluminium. It is suggested that aluminium‐induced tangles in the rabbit could serve as a model for the study of tangle formation.