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FURTHER OBSERVATIONS ON THE EXPERIMENTAL TRANSMISSION OF CREUTZFELDT‐JAKOB DISEASE FROM MAN TO SQUIRREL AND SPIDER MONKEYS
Author(s) -
ZLOTNIK I.,
GRANT D. P.,
DAYAN A. D.,
EARL C. J.,
ILLIS L. S.,
WELLER R. O.
Publication year - 1976
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1976.tb00490.x
Subject(s) - squirrel monkey , spider , biology , saimiri sciureus , pathological , incubation period , primate , physiology , pathology , zoology , medicine , anatomy , incubation , neuroscience , biochemistry
Inoculation of brain material from three female patients with Creutzfeldt‐Jakob disease into squirrel and spider monkeys produced an experimental neurological disease similar to Creutzfeldt‐Jakob disease in all the inoculated animals. The incubation period in squirrel monkeys varied from 17 to 29 months, but in the spider monkeys all the animals developed the disease between 19 and 22 months following inoculation. The early clinical signs were more readily recognized in squirrel monkeys than in spider monkeys. Itch and rubbing was a characteristic feature in all but one squirrel monkey, but it was absent in spider monkeys. The pathological change, in the form of widespread status spongiosus in the brain, as a rule was of greater severity in spider than in squirrel monkeys.