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THE NEUROPATHOLOGY OF THE FATTY LIVER AND KIDNEY SYNDROME OF CHICKS
Author(s) -
WIGHT P. A. L.
Publication year - 1975
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1975.tb00650.x
Subject(s) - biology , gliosis , medulla oblongata , pathology , spinal cord , choroid plexus , glycogen , cerebellum , anatomy , neuroglia , central nervous system , endocrinology , neuroscience , medicine
Sudanophilic lipid, probably triglyceride, was present in perivascular locations and in the cytoplasm of small cells in the brains of chickens with FLKS. The lipid was most consistently observed and was most abundant in the optic tectum and the cerebellum but in severely affected cases many regions of the central nervous system were implicated. The medulla oblongata and spinal cord were least often involved. The grey matter was predominantly affected. Degeneration, demyelination and gliosis were absent and there was no histological evidence of reduced amounts of glycogen in the lumbar glycogen body. Neurons and satellite cells of the spinal ganglia and autonomic plexuses, the epithelium of the choroid plexus and the cells of the epiphysis cerebri contained abnormal accumulations of lipid. Electron microscopy revealed that the greater part of the lipid was in the perikaryon and processes, particularly the endfeet, of astrocytes. Some lipid was also present in ganglionic neurons. Apart from the lipid droplets, the astrocytes and all other cells observed at the ultrastructural level, were morphologically normal.