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α‐TOCOPHEROL RESPONSIVE MUSCULAR DYSTROPHY IN GUINEA PIGS
Author(s) -
HOWELL J. McC.,
BUXTON P. H.
Publication year - 1975
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1975.tb00377.x
Subject(s) - myopathy , tocopherol , muscular dystrophy , guinea pig , hindlimb , medicine , vitamin e deficiency , physiology , alpha tocopherol , weakness , biology , vitamin e , anatomy , endocrinology , pathology , biochemistry , antioxidant
Hind limb weakness occurred sporadically in a colony of guinea pigs. This was found to be associated with a severe myopathy. The myopathy was found to respond to a‐tocopherol administration. This was clearly demonstrated by a dramatic fall in CPK levels after treatment. The tissues of the animals and their pelleted food had very low contents of vitamins A and E.