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CELL DEATH IN THE GERMINAL LAYERS OF THE POSTNATAL RAT BRAIN
Author(s) -
LEWIS P. D.
Publication year - 1975
Publication title -
neuropathology and applied neurobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.538
H-Index - 95
eISSN - 1365-2990
pISSN - 0305-1846
DOI - 10.1111/j.1365-2990.1975.tb00374.x
Subject(s) - fragmentation (computing) , programmed cell death , ependymal cell , biology , pathology , germinal center , anatomy , microbiology and biotechnology , central nervous system , neuroscience , apoptosis , medicine , immunology , genetics , ecology , b cell , antibody
In normal rats aged up to 21 days, between 0.2% and 06% of the cells in the sub‐ependymal and external granular layers show nuclear pyknosis and fragmentation. These cells are postmitotic. In control animals, an estimated 3.2% or less of newly acquired neurones and glia are lost by cell death. In undernourished rats, more pyknotic nuclei are found in the germinal layers of the brain at 12 days, when loss of newly acquired cells may be 3.7–7.8%.