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Comparison of calculations to estimate gastric emptying half‐time of solids in humans
Author(s) -
Zinsmeister A. R.,
Bharucha A. E.,
Camilleri M.
Publication year - 2012
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2012.01982.x
Subject(s) - gastric emptying , medicine , gastroenterology , stomach
Background Measuring solid gastric emptying (GE) at 4 h is used to identify gastroparesis. GE half‐time (GE T 1/2 ) is useful to assess overall and early GE. Aim To examine the validity of hourly imaging as a measurement of GE T 1/2 compared with estimates from more detailed imaging. Methods 155 human subjects (99 female, 56 male) underwent scintigraphic GE of a solid–liquid meal. We calculated the GE T 1/2 using linear interpolation based on a full set of abdominal images obtained over 4 h, and the GE T 1/2 based on images at 1, 2, 3, and 4 h after the meal with interpolation of data. Key Results Differences in GE T 1/2 values (entire set of scan times compared with just the hourly scans) were small [overall median (5th, 95th percentiles) = −0.2[−7.5, 4.6] min] with slightly greater differences in males compared with females. The agreement between the two methods was very high [concordance correlation coefficient (CCC) (95% CI) = 0.993 (0.990, 0.995)] and a Bland–Altman plot indicated the variation in the results between the two methods did not change appreciably across the range of GE studied (within ±10 min for all but four subjects). Calculated GE T 1/2 values, omitting the 3‐h data from the hourly measurements, were associated with similar high accuracy overall and for fast GE, but were less accurate with slow GE. Conclusions & Inferences Results of GE T 1/2 solids, using hourly imaging over 4 h, are accurate in the range 75–235 min which reflects the typical range of GE of solids in health and disease.