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Irritable bowel syndrome is more frequent in patients hospitalized for ischaemic colitis: results of a case–control study
Author(s) -
Hervé S.,
Beaugerie L.,
Bouhnik Y.,
Savoye G.,
Colombel J.f.,
Dyard F.,
Hourmandollivier I.,
Dao T.,
Vial M.,
Lerebours E.
Publication year - 2009
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2009.01333.x
Subject(s) - medicine , irritable bowel syndrome , odds ratio , confidence interval , gastroenterology , case control study , epidemiology
It has been suspected that there is an epidemiological link between irritable bowel syndrome (IBS) and ischaemic colitis (IC). We performed a retrospective case–control study to compare the frequency of IBS in patients hospitalized for IC compared with that of patients with peptic ulcer bleeding. Cases were patients with a first episode of IC and controls were patients with a first episode of peptic ulcer bleeding, matched to cases for sex and 10‐year age‐class. Diagnosis of IBS was based on medical information extracted from hospital medical files and a standard self‐questionnaire. The association between IBS and IC was tested using Mc Nemar’s paired odds ratio (OR); confidence interval at 95% (CI 95%) was calculated; Mantel–Haenzel’s Chi 2 was applied. A total of 113 cases and 113 matched controls were studied. There were 37 males and 76 females and the mean age was 69 ± 15 years in each group. The prevalence of IBS in cases was 16.9% vs 1.8% in controls. The risk of IBS was 11.05 times higher among cases than in controls ( P < 0.001); CI 95%: (2.45–49.74). A total of 87 pairs with complete data were used for OR calculation. The risk of IBS was 7.5 times higher in cases than in controls ( P = 0.002); CI 95%: (1.72–32.80). This case–control study shows that IBS is more frequent in IC patients than in controls.