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Clinical effects of STW 5 (Iberogast ® ) are not based on acceleration of gastric emptying in patients with functional dyspepsia and gastroparesis
Author(s) -
Braden B.,
Caspary W.,
Börner N.,
Vinson B.,
Schneider A. R. J.
Publication year - 2009
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2008.01249.x
Subject(s) - gastroparesis , gastric emptying , placebo , gastroenterology , medicine , breath test , clinical endpoint , clinical trial , stomach , pathology , helicobacter pylori , alternative medicine
STW 5, a herbal extract, is effective for the treatment of symptoms in patients with functional dyspepsia (FD). However, its mode of action is still unclear and a modulation of gastric motility is hypothesized. This multicentre, placebo‐controlled double‐blind study addressed the question of whether STW 5 accelerates gastric emptying in patients with FD and gastroparesis. One‐hundred and three patients diagnosed with FD were randomly assigned to a treatment with either STW 5 or a liquid placebo for 28 days. The primary end point of the study was a change of a validated gastrointestinal symptom (GIS) score under treatment. Additionally, patients underwent a 13 C octanoic acid breath test for the assessment of the gastric half‐emptying time ( t 1/2 ). Patients with prolonged t 1/2 were diagnosed with gastroparesis and requested to repeat the test at the end of treatment. A change of t 1/2 was defined a secondary study end point. t 1/2 was prolonged in 48.6% of patients in the STW 5 group and in 43.8% of the placebo group. During treatment, t 1/2 increased non‐significantly in patients treated with STW 5 (+23 ± 109 min; P = 0.51) and slightly accelerated among patients in the placebo arm (−26 ± 51 min; P = 0.77) ( P = 0.49). The improvement of the GIS ( P = 0.08) and the proportion of patients with a treatment response ( P = 0.03) were more pronounced in the STW 5 group. Our findings suggest that the clinical effects of STW 5 in patients with FD and gastroparesis are not directly mediated by an acceleration of gastric emptying. A clear‐cut correlation with symptom improvement is still lacking.