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Mechanisms of serotonergic agents for treatment of gastrointestinal motility and functional bowel disorders
Author(s) -
Kindt S.,
Tack J.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2007.00966.x
Subject(s) - serotonergic , serotonin , motility , tegaserod , gastrointestinal tract , serotonin antagonists , 5 ht receptor , medicine , receptor , pharmacology , irritable bowel syndrome , biology , microbiology and biotechnology
Most of the body's serotonin is released in the gut where it plays an important role in the control of gastrointestinal (GI) motility, sensitivity and muscle tone by activating different receptor subtypes. This review focuses on the known effects of selective serotonin reuptake inhibitor and serotonin receptor agonists and antagonists on the sensorimotor function of the GI tract and describes the therapeutic potential of these actions for GI motility and functional bowel disorders.