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Importance of 5‐hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity
Author(s) -
Greenwoodvan Meerveld B.
Publication year - 2007
Publication title -
neurogastroenterology and motility
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.489
H-Index - 105
eISSN - 1365-2982
pISSN - 1350-1925
DOI - 10.1111/j.1365-2982.2007.00964.x
Subject(s) - 5 ht receptor , irritable bowel syndrome , serotonin , receptor , afferent , gastrointestinal tract , visceral pain , medicine , neuroscience , endocrinology , biology , nociception
Serotonin (5‐HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5‐HT is mediated by specific 5‐HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT 3 , 5HT 4 , and 5HT 2B receptor‐mediated mechanisms in the regulation of visceral sensitivity.